Shonzilla, a pattern-seeking animal

Life is a game of patterns and chance, and those who play well will win.

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Thu Sep 17

It’s now obvious that social networking and social media are becoming an integral part of everyday life of more and more people and that the some basic rules of business are changing, namely how relevance and reputation and won and maintained.

The video above tackles the question whether “social media is a fad?”. It was created by Erik Qualman as a part of the campaign for his Socialnomics book on the business of social media.

I might add one correction to the video though. Facebook must be the 3rd most populated country on planet by now. :-) It had 300 million users 2 days ago and USA is estimated to have 307 million.

[video via Jackson Bond]

Sat Apr 25
Sat Oct 25
Sun Oct 12

Personal genomics

Welcome to the new field of personal genomics where you can learn about your genetic heritage and, as many (venture investors and insurance companies alike) might hope know, about health risks written in your genes.

Thanks to the exponential advancement of computing power (a phenomenon called Moore’s law) contributed to the birth of fields of bioinformatics and computational biology, that computer-aided data processing. In human genome (everyone reading this has it) there 3 billion DNA base pairs and only a small fraction makes us differ one from another - only as little as 0.02%. Also, it is the genes that bear information inside our organisms about our susceptibility for any of the hereditary diseases from a long list of genetic disorders. A variation in a DNA gene that makes a difference (functional like cancer or physical like height) is single nucleotide polymorphism (SNP, pronounced snip) and it occurs on a single nucleotide, as it name implies.

In an attempt to map the human genome from the physical and functional standpoint the Human Genome Project was initiated in 1990. It was a exceptionally successful attempt, exceeding all expectations and time estimations (probably due to longevity of Moore’s law) with the complete human genome being mapped (or genotyped) in 2003. In the process genes in human DNA were identified with the total count ending up in 20.000-25.000 range, since not all of us need to have all the distinguishing genes or snips present.

Bringing this process to masses became increasingly important. Over the years a lot of research in IT, bioinformatics and computational biology has been carried out and the genotyping process became available to everyone. This field is now appropriately called personal genomics. The main output is a list of mapped snips.

There are several companies offering genotyping services:
1. 23andme (CEO is Sergey Brin’s wife, so it’s logical why Google backed this company) - $400 for 600.000 snips, delivering report on 23 clinical conditions (incl. the obvious eye color and less obvious muscle performance) and 68 research reports
2. deCODEme (from Island) - $985 for 1.000.000 snips, while estimating risk of 29 diseases
3. Navigenics (several software engineers fled from Google and Apple to this company) - $2500 for $900.000, while estimating risk of over 20 diseases with the list increasing
4. other much more expensive options

The business plan for 23andme is to offer a social networking features around genes allowing its users to find to other users strangers with similar genetic variations. 23andme users can have their DNA scanned anonymously. They seem to have user’s privacy as a top priority, and we’re supposed to be impressed with HTTPS used exclusively to access their site and results, upon genotyping is complete.

Navigenics claims to be more medically oriented service, updating its users with new medical research information as they become available.

deCODEme follows the similar approach as 23andme, allowing you to connect to your genetic friends.

One interesting aspect and positive side-effect of doing genotyping your DNA might be getting your genome file and cross-referencing it agains the encyclopedia of snips called SNPedia. There’s a tool called Promethease you can use on your genome file and have it compared to the latest genome research.using

Sounds interesting, doesn’t it?

But would you do it?
Would you be concerned about privacy?
Insurance companies learning about your health risks?

Sun Feb 3

Sign of the space-time

(I am updating this entry with a map and open invitation) 

Guys over at Dopplr have published on their blog a map showing where their members (I might call Web2.0 early adopters) have travelled in 2007.

In the spirit of time (Zeitgeist in German they call this Raumzeitgeist, the spirit of the space-time and results can be seen here:

Dopplr Raumzeitgeist 2007: Where we went last year

Hopefully everyone out there will have at least one dot away from home this year.

Dopplr requires registration, but it’s invite-only. If you need one, let me know.

[via Dopplr Blog